Viral Replication Compartments or VRCs are nuclear mebraneless sub-compartments forming during infection of nuclear-replicating DNA viruses (e.g. HSV-1 (33923223). VRCs concentrate viral DNA as well as facilitating factors in the nucleus of an infected cell. (24257611)
Formation, Composition & dynamics (Assembly and disassembly)
Relation to human diseases
Proteome
References
Seyffert M, Georgi F, Tobler K, Bourqui L, Anfossi M, Michaelsen K, Vogt B, Greber UF, Fraefel C. The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments. Int J Mol Sci. 2021 Apr 24;22(9):4447. doi: 10.3390/ijms22094447. PMID: 33923223; PMCID: PMC8123221.
Schmid M, Speiseder T, Dobner T, Gonzalez RA. DNA virus replication compartments. J Virol. 2014 Feb;88(3):1404-20. doi: 10.1128/JVI.02046-13. Epub 2013 Nov 20. PMID: 24257611; PMCID: PMC3911613.