Nuclear bodies are membraneless, RNA-rich organelles in the cell nucleus that concentrate certain nuclear proteins and RNA-protein complexes.
MORC3 forms phase-separated condensates with liquid-like properties in the cell nucleus, called MORC2 nuclear bodies (NBs).
Formation, Composition & dynamics (Assembly and disassembly)
Relation to human diseases
Proteome
Formation, Composition & dynamics (Assembly and disassembly)
MORC3's phase separation in vitro is driven by its ATPase activity, which requires DNA binding and the release of MORC3's CW domain-dependent autoinhibition via connection with histone H3 (31284181).
Note: contain only one protein MORC3
Relation to human diseases
Microrchidia 3 (MORC3) ATPase is associated with a number of human diseases.
17332504 suggested that MORC3 regulates p53 activity and localization into PML-NBs.
27440897 showed MORC3 as an antiviral factor playing role during HSV-1 and HCMV infection.
Organism: Escherichia coli (strain K12).
Organism: Homo sapiens.
Organism: Arabidopsis thaliana.
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Organism: Mus musculus.
References
Takahashi K, Yoshida N, Murakami N, Kawata K, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Zinn AR, Shime H, Inoue N. Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell. 2007 May;18(5):1701-9. doi: 10.1091/mbc.e06-08-0747. Epub 2007 Mar 1. PMID: 17332504; PMCID: PMC1855011.
Sloan E, Orr A, Everett RD. MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus. J Virol. 2016 Sep 12;90(19):8621-33. doi: 10.1128/JVI.00621-16. PMID: 27440897; PMCID: PMC5021396.