Nuclear dicing bodies are nuclear bodies that play an important role in miRNAs play a control of gene expression. In plant cells, miRNA processing is a two-step process that takes place inside the nucleus by the enzyme Dicer-like1 (DCL1) and other proteins such as Serrate (SE), a zinc-finger domain protein, and Hyponastic Leaves1, a double-stranded RNA (dsRNA) binding-domain protein (HYL1). It is recently found that dicing bodies are phase separated condensates and their assembly is driven by the phase separation of SE (17442570, 33288888).
Formation, Composition & dynamics (Assembly and disassembly)
Relation to human diseases
Proteome
References
Fang Y, Spector DL. Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants. Curr Biol. 2007 May 1;17(9):818-23. doi: 10.1016/j.cub.2007.04.005. Epub 2007 Apr 19. PMID: 17442570; PMCID: PMC1950788.
Xie D, Chen M, Niu J, Wang L, Li Y, Fang X, Li P, Qi Y. Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis. Nat Cell Biol. 2021 Jan;23(1):32-39. doi: 10.1038/s41556-020-00606-5. Epub 2020 Dec 7. PMID: 33288888.