Misfolding in P62 is linked to defect in selective autophagy and Amyotrophic lateral sclerosis (ALS) which is a neurodegenerative disease that affects motor neurons in the brain, brainstem, and spinal cord (28159418, 23912309,25510538, 27064076).
Formation, Composition & dynamics (Assembly and disassembly)
Relation to human diseases
Proteome
References
Nakano S, Oki M, Kusaka H. The role of p62/SQSTM1 in sporadic inclusion body myositis. Neuromuscul Disord. 2017 Apr;27(4):363-369. doi: 10.1016/j.nmd.2016.12.009. Epub 2016 Dec 29. PMID: 28159418.
Richter-Landsberg C, Leyk J. Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration. Acta Neuropathol. 2013 Dec;126(6):793-807. doi: 10.1007/s00401-013-1158-x. Epub 2013 Aug 3. PMID: 23912309.
Mastaglia FL, Needham M. Inclusion body myositis: a review of clinical and genetic aspects, diagnostic criteria and therapeutic approaches. J Clin Neurosci. 2015 Jan;22(1):6-13. doi: 10.1016/j.jocn.2014.09.012. Epub 2014 Dec 12. PMID: 25510538.
Parakh S, Atkin JD. Protein folding alterations in amyotrophic lateral sclerosis. Brain Res. 2016 Oct 1;1648(Pt B):633-649. doi: 10.1016/j.brainres.2016.04.010. Epub 2016 Apr 7. PMID: 27064076.