PML bodies are nuclear condensates detected by the PML protein, as their name suggests. The PML protein polymerizes into spherical shells where it concentrates several unrelated partner proteins into the PML bodies. PML is found in nearly all normal human tissues and produces PML bodies, which play a role in gene regulation and cellular activities like DNA repair, cell cycle control, and cell fate decisions (20452955, 29723661).
Lallemand-Breitenbach V, de Thé H. PML nuclear bodies. Cold Spring Harb Perspect Biol. 2010 May;2(5):a000661. doi: 10.1101/cshperspect.a000661. Epub 2010 Apr 21. PMID: 20452955; PMCID: PMC2857171.
Lallemand-Breitenbach V, de Thé H. PML nuclear bodies: from architecture to function. Curr Opin Cell Biol. 2018 Jun;52:154-161. doi: 10.1016/j.ceb.2018.03.011. Epub 2018 Apr 30. PMID: 29723661.