RNP granules are membrane-less organelles composed of RNA and proteins. RNA-binding proteins are key components of RNP granules. RNP granules deliver localized mRNAs delivered to areas of local protein synthesis.
32763254 reviewd the pathophysiological implications of RNP granules in some neurodegenerative diseases.
Insulin-like growth factor II mRNA-binding protein (IMP) zip code-binding proteins participate in mRNA localization, and in motile cells IMP-containing granules are dispersed around the nucleus and in cellular protrusions (17289661).
Formation, Composition & dynamics of SGs (Assembly and disassembly)
IMP1 granules are unique RNP granules measuring between 100–300 nm in diameter and consisted of IMPs, 40 S ribosomal subunits, shuttling heterologous nuclear RNPs, poly(A)-binding proteins, and mRNAs (17289661).
17289661 isolated IMP1 containing RNP granules and dtermined their distinct physical properties.
17289661 determined the protein and mRNA composition of IMP1 granules.
Organism: Drosophila melanogaster
Organism: Caulobacter vibrioides (strain ATCC 19089 / CB15) (190650).
Desai P, Bandopadhyay R. Pathophysiological implications of RNP granules in frontotemporal dementia and ALS. Neurochem Int. 2020 Nov;140:104819. doi: 10.1016/j.neuint.2020.104819. Epub 2020 Aug 5. PMID: 32763254.
Jønson L, Vikesaa J, Krogh A, Nielsen LK, Hansen Tv, Borup R, Johnsen AH, Christiansen J, Nielsen FC. Molecular composition of IMP1 ribonucleoprotein granules. Mol Cell Proteomics. 2007 May;6(5):798-811. doi: 10.1074/mcp.M600346-MCP200. Epub 2007 Feb 7. PMID: 17289661.
Fabian G. The demonstration of the lymph pathways in the haemolymph nodes of cattle, and their relationship to the lymphatic system. Lymphology. 1981 Mar;14(1):7-16. PMID: 7289661.