Under normal circumstances, the tau protein It is one of the most soluble proteins known, but it becomes one of the most insoluble proteins known when it aggregates in a variety of disorders. Tau is a crucial component of the tauopathies, a group of diseases that includes Alzheimer's disease (32096047).
Kosik KS, Han S. Tau Condensates. Adv Exp Med Biol. 2019;1184:327-339. doi: 10.1007/978-981-32-9358-8_24. PMID: 32096047.