Transcriptional condensates are bimolecular condensates which form by phase separation of transcription factors, mediator cofactors and numerous nucleic-acid binding proteins at enhancer sites of gene loci, promoting bimolecular interactions which are necessary for gene expression ( 32929202, 31563432,30449618).
Formation, Composition & dynamics (Assembly and disassembly)
Relation to human diseases
Proteome
References
Wei MT, Chang YC, Shimobayashi SF, Shin Y, Strom AR, Brangwynne CP. Nucleated transcriptional condensates amplify gene expression. Nat Cell Biol. 2020 Oct;22(10):1187-1196. doi: 10.1038/s41556-020-00578-6. Epub 2020 Sep 14. PMID: 32929202.
Zamudio AV, Dall'Agnese A, Henninger JE, Manteiga JC, Afeyan LK, Hannett NM, Coffey EL, Li CH, Oksuz O, Sabari BR, Boija A, Klein IA, Hawken SW, Spille JH, Decker TM, Cisse II, Abraham BJ, Lee TI, Taatjes DJ, Schuijers J, Young RA. Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes. Mol Cell. 2019 Dec 5;76(5):753-766.e6. doi: 10.1016/j.molcel.2019.08.016. Epub 2019 Sep 25. PMID: 31563432; PMCID: PMC6898777.
Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, Schuijers J, Lee TI, Taatjes DJ, Young RA. Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains. Cell. 2018 Dec 13;175(7):1842-1855.e16. doi: 10.1016/j.cell.2018.10.042. Epub 2018 Nov 15. PMID: 30449618; PMCID: PMC6295254.