WNK bodies are large distinct foci which form in the distal convoluted tubule (DCT) as the result of potassium imbalance. WNK body formation is dependent on kidney-specific WNK1 (KS-WNK1), a truncated kinase-defective WNK1 isoform that is strongly expressed in the DCT (29237822).
Boyd-Shiwarski CR, Shiwarski DJ, Roy A, Namboodiri HN, Nkashama LJ, Xie J, McClain KL, Marciszyn A, Kleyman TR, Tan RJ, Stolz DB, Puthenveedu MA, Huang CL, Subramanya AR. Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent. Mol Biol Cell. 2018 Feb 15;29(4):499-509. doi: 10.1091/mbc.E17-08-0529. Epub 2017 Dec 13. PMID: 29237822; PMCID: PMC6014176.